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This is meant to give you a general idea about each of the medicines listed below. Only the most basic problems are listed. Ask your doctor if there are any other steps you need to take. Use each of them as your doctor tells you. If you have any questions or can’t follow the package instructions, call your doctor.

Hormonal therapies are used to treat prostate cancer. For cancer that's spread to the bones, others may be needed.

Hormonal Therapies

Luteinizing Hormone-releasing Hormone (LHRH) Analogs

  • Leuprolide
  • Goserelin

Anti-androgens

  • Flutamide
  • Bicalutamide
  • Nilutamide
  • Enzalutamide

Androgen Suppressants

  • Ketoconazole

CYP17A1 Inhibitors

  • Abiraterone

Bisphosphonates

  • Zoledronic acid
  • Pamidronate
  • Alendronate
  • Risedronate
  • Ibandronate

Denosumab

Hormonal

Hormonal therapies

Prostate cells need androgens to grow and work the way they're supposed to. The aim is to lower these amounts in your body. This is done to keep the prostate cells from being stimulated to grow. The best way to do this is by removing the testicles (orchiectomy). This can be done with surgery, but it can't be reversed.

In most cases, hormonal therapies are combined. The types are:

Lhrh

Luteinizing hormone-releasing hormone (lhrh) analogs

  • Leuprolide
  • Goserelin

These will lower the amount of testosterone made by the testicles. These are given as a shot every few months.

Some problems are:

Anti

Anti-androgens

  • Flutamide
  • Bicalutamide
  • Nilutamide

These will keep your body from using androgens.

Some problems are:

  • Nausea or vomiting
  • Diarrhea
  • Breast growth or tenderness—gynecomastia
  • Changes in sex drive

Suppress

Androgen suppressants

Ketoconazole

This medicine blocks androgens from being made. It's mainly when other medicines aren't working.

Some problems are:

  • Nausea or vomiting
  • Itchy skin
  • Liver problems

Cyp17a1

Cyp17a1 inhibitors

  • Abiraterone

This will block an enzyme needed to make testosterone in the organs where it's made.

Bis

Bisphosphonates

  • Zoledronic acid—as an IV
  • Pamidronate
  • Alendronate
  • Risedronate
  • Ibandronate

Prostate cancer usually spreads to the bones. This can cause pain, weakened bones, and a higher risk of broken bones. Bisphosphonates are used to slow bone loss, raise bone density, and lower the risk of broken bones. Most of these are taken as a pill.

Some problems are:

Den

Denosumab

Denosumab boosts the body's immune system. It blocks the development of cells that break down bone tissue. It is given as a shot every 4 weeks.

Possible side effects include:

  • Joint and muscle pain
  • Low calcium levels in the blood—hypocalcemia
  • Flu-like symptoms
  • Headache
  • Nausea or vomiting
  • Jaw bone damage
  • Higher risk of an unusual thigh bone fracture

Special considerations

If you are taking medicines:

  • Take the medicine as directed. Don’t change the amount or the schedule.
  • Ask what side effects could occur. Report them to your doctor.
  • Talk to your doctor before you stop taking any prescription medicine.
  • Don’t share your prescription medicine.
  • Medicines can be dangerous when mixed. Talk to your doctor or pharmacist if you are taking more than one medicine. This includes over-the-counter products and supplements.
  • Plan for refills as needed.