Cascara sagrada means ‘sacred bark’ in Spanish. The bark of this tree, which grows mostly on the west coast of the United States and parts of South America,1 is mainly used to treat constipation. Cascara sagrada can be found as an ingredient in over-the-counter laxatives.2 In addition to relieving constipation, cascara sagrada has also been used by Native Americans to treat liver problems, gallstones, joint and muscle pain, gonorrhea, indigestion, upset stomach, and dysentery (infection in the intestines that causes pain, fever, and diarrhea).2

Cascara sagrada bark contains anthraquinones. Anthraquinones are substances found in plants that give them their color. Because of this, they have been used as dyes. Certain anthraquinones in cascara sagrada, called cascarosides A and B, are also responsible for the bark’s laxative effect. When a person ingests the bark, the cascarosides interact with bacteria living in the large intestine to form substances that stimulate the intestine to move the bowels.3

Cascara sagrada is available as an over-the-counter laxative in the forms of tablets, capsules, and liquids.

In its raw form, the bark cannot safely be used until it is at least one year old or heated to above 212°F (100°C). Bark that is young or untreated has too strong of a laxative effect and produces severe intestinal spasm and cramping.3

The recommend dose of cut or powdered aged bark is 1-2 grams per day (containing 20-30 milligrams of cascaroside A). However, since few people consume the raw bark, dosages vary considerably depending on the product containing cascara sagrada. Therefore, it is best to check the product label for the appropriate dosage.

Make sure to read the label if you are considering the laxative for a child, as there may be instructions specific to children. Cascara should not be used by children under 12 unless specifically recommended by their physician.

Overdosing on laxatives can cause nausea, vomiting, abdominal cramping, and dehydration. Taking too much cascara sagrada may also lead to abdominal pain, diarrhea, collapse, bloody stools, and in extreme cases, electrolyte abnormalities and heart rhythm disturbances.6

Cascara sagrada is most often used to treat constipation.


In a review of laxatives used in the treatment of chronic diarrhea, researchers were unable to uncover any studies on the effectiveness of cascara sagrada alone or in combination with other laxatives.11 The evidence for its benefit is based on its traditional use and the known effects of cascaroside anthraquinones on bowel stimulation.

A few case reports have linked cascara sagrada to serious liver problems.5,8,7

Cascara sagrada should be avoided in cases of intestinal blockage, inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis), appendicitis, or abdominal pain of unknown origin.10

Since little safety information is available, women who are pregnant or lactating and children under 12 years old should not use cascara sagrada.3

Some people taking cascara sagrada may develop a dependency on the laxative.3

Frequent use may also cause a change in color of the stools and urine, however this is not harmful.3,4 Harmless pigmentation inside the colon may also occur.

Chronic use, meaning using the laxative for more than seven days, may lead to fluid and electrolyte loss (eg, potassium) and loss of proper intestinal muscle contractions. This effect may be increased if you are taking heart medicines, diuretics, corticosteroids, or licorice root.9